It all started with a string of people telling me how I looked younger than my age. Shaving my beard didn’t help either.
Then a friend was mocking me on how childish I appears on some of my last photos. And was jocking I might be affected by a mutation on Klotho-related genes.
What the fuck is that? Turns out it really exist, and there’s a SNP tied to that hormone and called rs9536314 .
Luckily, it is a SNP covered by the first generation of 23andMe chips. Having
downloaded the raw data a while back, it is a matter of installing the Python
$ pip install arv Collecting arv Downloading arv-0.9.2-cp27-none-macosx_10_12_intel.whl (92kB) 100% |████████████████████████████████| 102kB 10kB/s Collecting cython>=0.25 (from arv) Downloading Cython-0.25.2-cp27-cp27m-macosx_10_6_intel.macosx_10_9_intel.macosx_10_9_x86_64.macosx_10_10_intel.macosx_10_10_x86_64.whl (4.1MB) 100% |████████████████████████████████| 4.1MB 201kB/s Installing collected packages: cython, arv Successfully installed arv-0.9.2 cython-0.25.2
Let’s now find out about that SNP:
$ python Python 2.7.13 (default, Dec 18 2016, 07:03:39) [GCC 4.2.1 Compatible Apple LLVM 8.0.0 (clang-800.0.42.1)] on darwin Type "help", "copyright", "credits" or "license" for more information. Persistent session history, tab completion and pretty printing are enabled. >>> from arv import load >>> genome = load("kev_full_genome.txt") >>> genome["rs9536314"] <SNP: chromosome=13 position=33628138 genotype=<Genotype 'GT'>> >>>
Bingo! With the
GT variant, I’m supposed to have higher plasma klotho
concentration. Which is, according to some studies
, reported to:
- affect longevity in mice,
- associated with greater brain cortical volume,
- show lower less decline with age on standardized cognitive tests,
- score better on some Alzheimer’s disease tests.
As usual all these studies are preliminary and should be taken with a huge grain of salt.
But my friend’s diagnostic was right. My dear friend, you made my day and I owe you a mojito! ;)
And thanks Mom and Dad for your DNA! :)