It all started with a string of people telling me how I looked younger than my age. Shaving my beard didn’t help either.

Then a friend was mocking me on how childish I appears on some of my last photos. And was jocking I might be affected by a mutation on Klotho-related genes.

What the fuck is that? Turns out it really exist, and there’s a SNP tied to that hormone and called rs9536314 .

Luckily, it is a SNP covered by the first generation of 23andMe chips. Having downloaded the raw data a while back, it is a matter of installing the Python arv package:

$ pip install arv
Collecting arv
  Downloading arv-0.9.2-cp27-none-macosx_10_12_intel.whl (92kB)
    100% |████████████████████████████████| 102kB 10kB/s
Collecting cython>=0.25 (from arv)
  Downloading Cython-0.25.2-cp27-cp27m-macosx_10_6_intel.macosx_10_9_intel.macosx_10_9_x86_64.macosx_10_10_intel.macosx_10_10_x86_64.whl (4.1MB)
    100% |████████████████████████████████| 4.1MB 201kB/s
Installing collected packages: cython, arv
Successfully installed arv-0.9.2 cython-0.25.2

Let’s now find out about that SNP:

$ python
Python 2.7.13 (default, Dec 18 2016, 07:03:39)
[GCC 4.2.1 Compatible Apple LLVM 8.0.0 (clang-800.0.42.1)] on darwin
Type "help", "copyright", "credits" or "license" for more information.
Persistent session history, tab completion and pretty printing are enabled.
>>> from arv import load
>>> genome = load("kev_full_genome.txt")
>>> genome["rs9536314"]
<SNP: chromosome=13 position=33628138 genotype=<Genotype 'GT'>>

Bingo! With the GT variant, I’m supposed to have higher plasma klotho concentration. Which is, according to some studies , reported to:

  • affect longevity in mice,
  • associated with greater brain cortical volume,
  • show lower less decline with age on standardized cognitive tests,
  • score better on some Alzheimer’s disease tests.

As usual all these studies are preliminary and should be taken with a huge grain of salt.

But my friend’s diagnostic was right. My dear friend, you made my day and I owe you a mojito! ;)

And thanks Mom and Dad for your DNA! :)

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