Kevin Deldycke - Englishhttps://kevin.deldycke.com/2017-06-08T12:00:00+02:00Klotho Induced Longevity2017-06-08T12:00:00+02:002017-06-08T12:00:00+02:00Kevin Deldycketag:kevin.deldycke.com,2017-06-08:/2017/06/klotho-induced-longevity/<p>It all started with a string of people telling me how I looked younger than my age. Shaving my beard didn&rsquo;t help&nbsp;either.</p> <p>Then a friend was mocking me on how childish I appears on some of my last photos. And was jocking I might be affected by a …</p><p>It all started with a string of people telling me how I looked younger than my age. Shaving my beard didn&rsquo;t help&nbsp;either.</p> <p>Then a friend was mocking me on how childish I appears on some of my last photos. And was jocking I might be affected by a mutation on <em>Klotho</em>-related&nbsp;genes.</p> <p>What the fuck is that? Turns out it really exist, and there&rsquo;s a <span class="caps">SNP</span> tied to that hormone and called <a href="https://www.snpedia.com/index.php/Rs9536314">rs9536314 </a>.</p> <p>Luckily, it is a <span class="caps">SNP</span> covered by the first generation of 23andMe chips. Having downloaded the raw data a while back, it is a matter of installing the Python <a href="https://github.com/cslarsen/arv"><code>arv</code></a>&nbsp;package:</p> <div class="highlight"><pre><span></span><span class="err">$</span> <span class="n">pip</span> <span class="n">install</span> <span class="n">arv</span> <span class="n">Collecting</span> <span class="n">arv</span> <span class="n">Downloading</span> <span class="n">arv</span><span class="o">-</span><span class="mf">0.9</span><span class="o">.</span><span class="mi">2</span><span class="o">-</span><span class="n">cp27</span><span class="o">-</span><span class="n">none</span><span class="o">-</span><span class="n">macosx_10_12_intel</span><span class="o">.</span><span class="n">whl</span> <span class="p">(</span><span class="mi">92</span><span class="n">kB</span><span class="p">)</span> <span class="mi">100</span><span class="o">%</span> <span class="o">|</span><span class="err">████████████████████████████████</span><span class="o">|</span> <span class="mi">102</span><span class="n">kB</span> <span class="mi">10</span><span class="n">kB</span><span class="o">/</span><span class="n">s</span> <span class="n">Collecting</span> <span class="n">cython</span><span class="o">&gt;=</span><span class="mf">0.25</span> <span class="p">(</span><span class="kn">from</span> <span class="nn">arv</span><span class="p">)</span> <span class="n">Downloading</span> <span class="n">Cython</span><span class="o">-</span><span class="mf">0.25</span><span class="o">.</span><span class="mi">2</span><span class="o">-</span><span class="n">cp27</span><span class="o">-</span><span class="n">cp27m</span><span class="o">-</span><span class="n">macosx_10_6_intel</span><span class="o">.</span><span class="n">macosx_10_9_intel</span><span class="o">.</span><span class="n">macosx_10_9_x86_64</span><span class="o">.</span><span class="n">macosx_10_10_intel</span><span class="o">.</span><span class="n">macosx_10_10_x86_64</span><span class="o">.</span><span class="n">whl</span> <span class="p">(</span><span class="mf">4.1</span><span class="n">MB</span><span class="p">)</span> <span class="mi">100</span><span class="o">%</span> <span class="o">|</span><span class="err">████████████████████████████████</span><span class="o">|</span> <span class="mf">4.1</span><span class="n">MB</span> <span class="mi">201</span><span class="n">kB</span><span class="o">/</span><span class="n">s</span> <span class="n">Installing</span> <span class="n">collected</span> <span class="n">packages</span><span class="p">:</span> <span class="n">cython</span><span class="p">,</span> <span class="n">arv</span> <span class="n">Successfully</span> <span class="n">installed</span> <span class="n">arv</span><span class="o">-</span><span class="mf">0.9</span><span class="o">.</span><span class="mi">2</span> <span class="n">cython</span><span class="o">-</span><span class="mf">0.25</span><span class="o">.</span><span class="mi">2</span> </pre></div> <p>Let&rsquo;s now find out about that <span class="caps">SNP</span>:</p> <div class="highlight"><pre><span></span><span class="err">$</span> <span class="n">python</span> <span class="n">Python</span> <span class="mf">2.7</span><span class="o">.</span><span class="mi">13</span> <span class="p">(</span><span class="n">default</span><span class="p">,</span> <span class="n">Dec</span> <span class="mi">18</span> <span class="mi">2016</span><span class="p">,</span> <span class="mo">07</span><span class="p">:</span><span class="mo">03</span><span class="p">:</span><span class="mi">39</span><span class="p">)</span> <span class="p">[</span><span class="n">GCC</span> <span class="mf">4.2</span><span class="o">.</span><span class="mi">1</span> <span class="n">Compatible</span> <span class="n">Apple</span> <span class="n">LLVM</span> <span class="mf">8.0</span><span class="o">.</span><span class="mi">0</span> <span class="p">(</span><span class="n">clang</span><span class="o">-</span><span class="mf">800.0</span><span class="o">.</span><span class="mf">42.1</span><span class="p">)]</span> <span class="n">on</span> <span class="n">darwin</span> <span class="n">Type</span> <span class="s2">&quot;help&quot;</span><span class="p">,</span> <span class="s2">&quot;copyright&quot;</span><span class="p">,</span> <span class="s2">&quot;credits&quot;</span> <span class="ow">or</span> <span class="s2">&quot;license&quot;</span> <span class="k">for</span> <span class="n">more</span> <span class="n">information</span><span class="o">.</span> <span class="n">Persistent</span> <span class="n">session</span> <span class="n">history</span><span class="p">,</span> <span class="n">tab</span> <span class="n">completion</span> <span class="ow">and</span> <span class="n">pretty</span> <span class="n">printing</span> <span class="n">are</span> <span class="n">enabled</span><span class="o">.</span> <span class="o">&gt;&gt;&gt;</span> <span class="kn">from</span> <span class="nn">arv</span> <span class="kn">import</span> <span class="n">load</span> <span class="o">&gt;&gt;&gt;</span> <span class="n">genome</span> <span class="o">=</span> <span class="n">load</span><span class="p">(</span><span class="s2">&quot;kev_full_genome.txt&quot;</span><span class="p">)</span> <span class="o">&gt;&gt;&gt;</span> <span class="n">genome</span><span class="p">[</span><span class="s2">&quot;rs9536314&quot;</span><span class="p">]</span> <span class="o">&lt;</span><span class="n">SNP</span><span class="p">:</span> <span class="n">chromosome</span><span class="o">=</span><span class="mi">13</span> <span class="n">position</span><span class="o">=</span><span class="mi">33628138</span> <span class="n">genotype</span><span class="o">=&lt;</span><span class="n">Genotype</span> <span class="s1">&#39;GT&#39;</span><span class="o">&gt;&gt;</span> <span class="o">&gt;&gt;&gt;</span> </pre></div> <p>Bingo! With the <code>GT</code> variant, I&rsquo;m supposed to have higher plasma klotho concentration. Which is, <a href="https://www.snpedia.com/index.php/Rs9536314">according to some studies </a>, reported&nbsp;to:</p> <ul> <li>affect longevity in&nbsp;mice,</li> <li>associated with greater brain cortical&nbsp;volume,</li> <li>show lower less decline with age on standardized cognitive&nbsp;tests,</li> <li>score better on some Alzheimer&rsquo;s disease&nbsp;tests.</li> </ul> <p>As usual all these studies are preliminary and should be taken with a huge grain of&nbsp;salt.</p> <p>But my friend&rsquo;s diagnostic was right. My dear friend, you made my day and I owe you a mojito!&nbsp;;)</p> <p>And thanks Mom and Dad for your <span class="caps">DNA</span>!&nbsp;:)</p>I’m a Hot Developer2017-04-24T12:00:00+02:002017-04-24T12:00:00+02:00Kevin Deldycketag:kevin.deldycke.com,2017-04-24:/2017/04/github-top-developer/<p>Just earned my bragging rights last month, with my <a href="https://github.com/kdeldycke/awesome-falsehood">Awesome List of Falsehoods Programmers Believe in</a>. Here&rsquo;s my repository, at the top of the&nbsp;charts:</p> <p><img alt="" src="/uploads/2017/github-top-hot-repositories.png"></p> <p>It was the direct effect of getting to the <a href="https://news.ycombinator.com/item?id=13637102">front page of Hacker News</a>.</p> <p>All that attention made me the <a href="https://twitter.com/kdeldycke/status/831451728625168384">top developer on GitHub …</a></p><p>Just earned my bragging rights last month, with my <a href="https://github.com/kdeldycke/awesome-falsehood">Awesome List of Falsehoods Programmers Believe in</a>. Here&rsquo;s my repository, at the top of the&nbsp;charts:</p> <p><img alt="" src="/uploads/2017/github-top-hot-repositories.png"></p> <p>It was the direct effect of getting to the <a href="https://news.ycombinator.com/item?id=13637102">front page of Hacker News</a>.</p> <p>All that attention made me the <a href="https://twitter.com/kdeldycke/status/831451728625168384">top developer on GitHub</a> for a couple of&nbsp;days:</p> <p><img alt="" src="/uploads/2017/github-top-trending-developer.png"></p> <p>Yes, my face, right above the heavy-weights of the&nbsp;industry.</p> <p>I wanted to <a href="https://genius.com/Incubus-you-will-be-a-hot-dancer-lyrics">be a hot dancer</a>. I ended up a hot developer. Next step would be to code in leopard thongs I&nbsp;guess.</p>Plumage 0.9 Released2017-03-22T12:00:00+01:002017-03-22T12:00:00+01:00Kevin Deldycketag:kevin.deldycke.com,2017-03-22:/2017/03/plumage-09-released/<p>Nine months in the making, here is version 0.9 of my <a href="https://github.com/kdeldycke/plumage">Plumage theme</a> for&nbsp;Pelican.</p> <p>Main change is the long awaited upgrade from Bootstrap 2.x to&nbsp;3.x.</p> <p>For more details, see the <a href="https://github.com/kdeldycke/plumage/tree/0.9#changelog">changelog </a>.</p><p>Nine months in the making, here is version 0.9 of my <a href="https://github.com/kdeldycke/plumage">Plumage theme</a> for&nbsp;Pelican.</p> <p>Main change is the long awaited upgrade from Bootstrap 2.x to&nbsp;3.x.</p> <p>For more details, see the <a href="https://github.com/kdeldycke/plumage/tree/0.9#changelog">changelog </a>.</p>Meta Package Manager V2.5.02017-03-01T22:30:00+01:002017-03-01T22:30:00+01:00Kevin Deldycketag:kevin.deldycke.com,2017-03-01:/2017/03/meta-package-manager-250/<p><a href="https://pypi.python.org/pypi/meta-package-manager/2.5.0">Meta Package Manager v2.5.0</a> has just been&nbsp;released.</p> <p>See the <a href="https://meta-package-manager.readthedocs.io/en/stable/changelog.html">changelog for more info</a>.</p><p><a href="https://pypi.python.org/pypi/meta-package-manager/2.5.0">Meta Package Manager v2.5.0</a> has just been&nbsp;released.</p> <p>See the <a href="https://meta-package-manager.readthedocs.io/en/stable/changelog.html">changelog for more info</a>.</p>Meta Package Manager V2.4.02017-01-28T20:00:00+01:002017-01-28T20:00:00+01:00Kevin Deldycketag:kevin.deldycke.com,2017-01-28:/2017/01/meta-package-manager-240/<p><a href="https://pypi.python.org/pypi/meta-package-manager/2.4.0">Meta Package Manager v2.4.0</a> has just been&nbsp;released.</p> <p>See the <a href="https://meta-package-manager.readthedocs.io/en/stable/changelog.html">changelog for more info</a>.</p><p><a href="https://pypi.python.org/pypi/meta-package-manager/2.4.0">Meta Package Manager v2.4.0</a> has just been&nbsp;released.</p> <p>See the <a href="https://meta-package-manager.readthedocs.io/en/stable/changelog.html">changelog for more info</a>.</p>